Scratching an itch is both satisfying and frustrating—offering momentary relief but often leading to even more irritation. However, a study reveals that scratching is more than just a reflexive habit. It not only worsens allergic inflammation but also plays a role in immune defense against infections.

The Science Behind Scratching and Inflammation

The study shows that pain-sensing neurons release substance P, a neuropeptide that stimulates mast cells—immune cells responsible for triggering inflammation. When activated, mast cells release histamines and other inflammatory molecules, leading to redness, swelling, and more itching. This creates a vicious cycle where scratching only exacerbates the problem instead of providing lasting relief.

Scratching: A Double-Edged Sword?

Interestingly, the study also found that scratching may have short-term benefits. It helps the body defend against Staphylococcus aureus, a common skin pathogen. By breaking the skin barrier, scratching can assist in clearing bacteria. However, this comes at a cost—long-term skin damage and increased inflammation, especially in individuals with eczema, chronic rashes, or allergic reactions.

Scratching synergizes with FcεRI mast cell activation to drive allergic skin inflammation.

Implications for Skin Health

For those struggling with chronic rashes, eczema, or allergic reactions, this research highlights the importance of breaking the itch-scratch cycle. Instead of scratching, dermatologists recommend alternative soothing methods, such as:

✔️ Applying cool compresses to soothe the skin

✔️ Using anti-inflammatory skincare ingredients (e.g., colloidal oatmeal, aloe vera, niacinamide)

✔️ Taking antihistamines to reduce itching

✔️ Keeping nails short to prevent skin damage

✔️ Using barrier-repairing moisturizers to strengthen the skin

Solution:

On the body: Tiger Balm Ointments (counter-irritants) can help distract from the itch and provide relief.

On the face:

1. Washing your face can help remove allergens and stop the itch.

Recommended product: Higher Capacity Cleansing Fluid (contains Symsitive(R), known for its skin-soothing properties, great for reducing irritation and discomfort caused by scratching).

1. If you have prolonged allergic dermatitis and feels itchy, consider using anti-histamine.
2. Combine with products strong in anti-inflammatory ingredients, such as turmeric, purslane, bisabolol and Symsitive(R)

By understanding the biological effects of scratching, we can take better steps to protect our skin and promote faster healing. Next time you feel the urge to scratch, remember—resisting it may be the best thing you can do for your skin!

References

Liu, B., He, S., He, S. H., Lin, T.-K., & Dong, X. (2024). Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation. Science, 383(6685), eadn9390. https://doi.org/10.1126/science.adn9390